While it is known that the new series will focus on the underlying storyline of Agent Phil Coulson's resurrection from his apparent demise at the hand of Loki in The Avengers, fans have also been wondering what kind of villainy will be seen each week. Co-creator Joss Whedon is known to use the weekly concept of the 'bad guy of the week' on his past television series and he is known to use a singular villain who crosses over into multiple episodes too.
While speaking with Joss's brother and co-showrunner Jed Whedon, The Hollywood Reporter asked Jed about Agents of SHIELD's weekly villainy.
"There are gods and aliens. So we have a lot to play with. There's a spy aspect of the show and SHIELD is some of the most sci-fi in the Marvel universe because it's about gadgets. So we have a lot of different things to play with.
"It will be a mixture of both. We will be focusing on having every story having a beginning, middle and end, but some of it will be mythology and some of it will standalone. And our character runs will continue through all of that."
But what about any villain cameos from the Marvel Cinematic Universe like Loki or Justin Hammer or other past villains? Various Marvel executives have hinted there's the possibility of cameos by stars of their movies—matter of fact The Avengers' Cobie Smulders (Maria Hill) is in tonight's premiere—however, fans will have to watch each week to see who may or may not show up on their living room TV.